![]() ![]() ![]() “We developed a roadmap to study the protein and cellular changes involved in worsening-as well as alleviating-symptoms of brain fog. “We have found neuroinflammation is a common theme across many brain disorders, but not all neuroinflammation is the same,” he noted. Hu is spearheading the characterization of cognitive impairment following mild-to-moderate COVID-19 at Rutgers. PMID: 37278994.įunding: NIH’s Researching COVID to Enhance Recovery (RECOVER) research program and National Heart, Lung, and Blood Institute (NHLBI).A leading cognitive neurologist and neuroscientist, Dr. ![]() References: Development of a Definition of Postacute Sequelae of SARS-CoV-2 Infection. RECOVER: Researching COVID to Enhance Recovery.Long COVID or Post-COVID Conditions (CDC).Long COVID: Community Engagement Alliance.Resources and Research about Long COVID.Autoimmune Response Found in Many With COVID-19.Long COVID Symptoms Linked to Inflammation.Paxlovid Reduces Serious Risks from Omicron Variants.Bivalent Boosters Provide Better Protection Against Severe COVID-19.*Editor's Note: This story was modified soon after publication to correct errors and clarify the findings. Andrea Foulkes of the RECOVER Data Resource Core, Harvard Medical School, and Massachusetts General Hospital.Ĭlinical trials run through RECOVER to address many of the symptoms highlighted in the current study are expected to begin enrolling participants by the end of 2023. “One of the big take-aways from this study is long COVID is not just one syndrome it’s a syndrome of syndromes,” says senior study author Dr. Other symptoms commonly reported along with the 12 differentiating ones include dry mouth, weakness, headaches, tremor, muscle and abdominal pain, fever, sweats, chills, and sleep disturbances. The authors note that this approach may evolve over time as researchers gain more insights into the symptoms of long COVID. The researchers also identified four clusters of symptoms that often occurred together. Among those infected during the Omicron era, reinfections were also linked to higher long COVID frequency and severity. Using these 12 symptoms, the researchers developed a score to best differentiate those who have been infected with COVID-19 from those who have not. The team found that long COVID was more common and severe in people infected before Omicron emerged and in those who were unvaccinated at the time of infection. Of these, 12 in particular best distinguish those with and without long COVID: post-exertional malaise (the worsening of symptoms after physical or mental activity), fatigue, brain fog, dizziness, gut symptoms, heart palpitations, sexual problems, change in smell or taste, thirst, chronic cough, chest pain, and abnormal movements such as muscle twitching or jerking. The team found that 37 symptoms were substantially more likely to occur in people who had been infected with COVID-19. Results were published on May 25, 2023, in JAMA. The researchers focused on symptoms that were reported by at least 2.5% of the study volunteers. In a new study, RECOVER scientists collected reports of symptoms from about 8,600 people who had been infected with COVID-19 and about 1,100 uninfected people. It’s also testing ways to detect, treat, and prevent the condition. RECOVER aims to understand why some people develop long-term symptoms following COVID-19. In 2021, NIH launched the Researching COVID to Enhance Recovery (RECOVER) initiative. It also hasn’t been clear whether different sets of long COVID symptoms may reflect distinct syndromes that need different treatments. The development of therapies for PASC has been challenged by a lack of an agreed-upon definition for the condition. These lingering health problems have become known as long COVID, or postacute sequelae of SARS-CoV-2 infection (PASC). Their effects can range from mild to disabling. They can affect nearly every tissue and organ in the body. An array of problems may linger for months or years after infection. Georgii / Adobe Stockįor many people, a bout with SARS-CoV-2, the virus that causes COVID-19, doesn’t end when the initial symptoms subside. Researchers are gaining a better understanding of the symptoms that can linger after recovering from COVID-19. ![]()
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